Computational Analyses

EDDY-PHBI

Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, Kim S, Mickler EA, Tuder RM, Chan SY, Geraci MW. Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome. American Journal of Respiratory Cell and Molecular Biology. 2018. Epub ahead of print.  https://doi.org/10.1165/rcmb.2018-0368OC  PMID 30562042.

25 FD  vs  58 PAH

PathwayDB# genesp-valJSNew DependencyRewiringEssentiality MediatorsSpecificity Mediators DDN
FORMATION OF ATP BY CHEMIOSMOTIC COUPLINGR160.00530.96750.000.62ATP5H ATP5A1 ATP5C1 ATP5B Image
MITOCHONDRIAL TRNA AMINOACYLATIONR210.00840.98820.470.80VARS2 CARS2 HARS2 Image
TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITIONR160.01040.94410.000.79ARHGEF18 CGN Image
TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSER140.01640.92200.000.46HLA-DQA1 ZAP70 CD3E CD4 Image
RNA POL I TRANSCRIPTION INITIATIONR250.02310.97050.080.72GTF2H3 CDK7 GTF2H4 RRN3 Image
CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEXR110.02680.94710.140.75ORC1 Image
DCC MEDIATED ATTRACTIVE SIGNALINGR130.02960.96040.040.67DOCK1 WASL NTN1 Image
AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATIONR170.03370.91960.650.68PYCR1 PHGDH Image
ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILONR140.03410.96470.050.89TLR3 TICAM1 RPS27A Image
TRNA AMINOACYLATIONR420.03420.96690.420.57DARS MARS VARS2 YARS YARS2 EPRS CARS2 MARS2 TARS2 VARS2 SARS2 NARS2 FARS2 PARS2 IARS2 LARS2 WARS2 AARS2 QARS Image
RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENTR120.03480.98190.431.00MPG LIG3 Image
MRNA DECAY BY 3 TO 5 EXORIBONUCLEASER110.03820.93800.060.71EXOSC6 Image
REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGENR250.03830.98640.140.78RBX1 CREBBP HIF3A Image
PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINSR160.04210.89150.000.57LCK CD4 CD3E Image
ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATIONR180.04820.94820.160.75RIPK2 MAP3K7 IRAK2 Image
MTORC1 MEDIATED SIGNALLINGR110.04890.97360.120.81EIF4E Image
MITOCHONDRIAL FATTY ACID BETA OXIDATIONR140.05480.9271
SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONSR120.05780.9175
YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSIONR240.06050.9899
ADP SIGNALLING THROUGH P2RY12R210.06190.9807
ETHANOL OXIDATIONR100.06610.9556
SYNTHESIS OF PER110.06820.9762
THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESISR280.07050.9723
TRANSFERRIN ENDOCYTOSIS AND RECYCLINGR250.07130.9779
DSCAM INTERACTIONSR110.07720.8513
G BETA GAMMA SIGNALLING THROUGH PI3KGAMMAR250.07940.9773
ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALINGR110.08150.9654
INFLAMMASOMESR170.08380.9799
TRAF3 DEPENDENT IRF ACTIVATIONR140.08750.9435
RNA POL I TRANSCRIPTION TERMINATIONR220.08950.8987
E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATIONR100.09100.9107
REGULATION OF KIT SIGNALINGR170.09260.9504
GLYCOSPHINGOLIPID METABOLISMR380.09370.9850
REGULATION OF SIGNALING BY CBLR180.09550.9639
OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHAR180.09690.9557
NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERSR210.09780.9651
ORGANIC CATION ANION ZWITTERION TRANSPORTR130.09870.9883
METABOLISM OF POLYAMINESR150.09990.9622