PHBI | SY Chan Lab

Computational Analyses

EDDY-PHBI

Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, Kim S, Mickler EA, Tuder RM, Chan SY, Geraci MW. Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome. American Journal of Respiratory Cell and Molecular Biology. 2018. Epub ahead of print. https://doi.org/10.1165/rcmb.2018-0368OC PMID 30562042.

25 FD vs 58 PAH

<table border="1" style="width:100%" id="t01" class="sortable"></tr><tr><th>Pathway</th><th>DB</th><th># genes</th><th>p-val</th><th>title="Jensen-Shannon Divergence between the condition-specific likelihood distributions">JS</th><th>title="Proportion of newly discovered dependencies compared to total number of edges">New Dependency</th><th>title="Proportion of condition-specific dependencies compared to total number of edges">Rewiring</th><th>title="Genes with large essentiality change between conditions. Color indicates condition with high essentiality.">Essentiality Mediators</th><th>title="Genes with largest proportion of condition-specific dependencies">Specificity Mediators</th><th>DDN</th></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING" target="_blank" style="text-decoration: none">FORMATION OF ATP BY CHEMIOSMOTIC COUPLING</a></td><td>R</td><td>16</td><td>0.0053</td><td>0.9675</td><td>0.00</td><td>0.62</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATP5H" target="_blank" style="text-decoration: none">ATP5H</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATP5A1" target="_blank" style="text-decoration: none">ATP5A1</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATP5C1" target="_blank" style="text-decoration: none">ATP5C1</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATP5B" target="_blank" style="text-decoration: none">ATP5B</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION" target="_blank" style="text-decoration: none">MITOCHONDRIAL TRNA AMINOACYLATION</a></td><td>R</td><td>21</td><td>0.0084</td><td>0.9882</td><td>0.47</td><td>0.80</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=VARS2" target="_blank" style="text-decoration: none">VARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CARS2" target="_blank" style="text-decoration: none">CARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=HARS2" target="_blank" style="text-decoration: none">HARS2</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION" target="_blank" style="text-decoration: none">TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION</a></td><td>R</td><td>16</td><td>0.0104</td><td>0.9441</td><td>0.00</td><td>0.79</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ARHGEF18" target="_blank" style="text-decoration: none">ARHGEF18</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CGN" target="_blank" style="text-decoration: none">CGN</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE" target="_blank" style="text-decoration: none">TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE</a></td><td>R</td><td>14</td><td>0.0164</td><td>0.9220</td><td>0.00</td><td>0.46</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=HLA-DQA1" target="_blank" style="text-decoration: none">HLA-DQA1</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZAP70" target="_blank" style="text-decoration: none">ZAP70</a> </td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CD3E" target="_blank" style="text-decoration: none">CD3E</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CD4" target="_blank" style="text-decoration: none">CD4</a> </td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION" target="_blank" style="text-decoration: none">RNA POL I TRANSCRIPTION INITIATION</a></td><td>R</td><td>25</td><td>0.0231</td><td>0.9705</td><td>0.08</td><td>0.72</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=GTF2H3" target="_blank" style="text-decoration: none">GTF2H3</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CDK7" target="_blank" style="text-decoration: none">CDK7</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=GTF2H4" target="_blank" style="text-decoration: none">GTF2H4</a> </td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=RRN3" target="_blank" style="text-decoration: none">RRN3</a> </td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX" target="_blank" style="text-decoration: none">CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX</a></td><td>R</td><td>11</td><td>0.0268</td><td>0.9471</td><td>0.14</td><td>0.75</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=ORC1" target="_blank" style="text-decoration: none">ORC1</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING" target="_blank" style="text-decoration: none">DCC MEDIATED ATTRACTIVE SIGNALING</a></td><td>R</td><td>13</td><td>0.0296</td><td>0.9604</td><td>0.04</td><td>0.67</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=DOCK1" target="_blank" style="text-decoration: none">DOCK1</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=WASL" target="_blank" style="text-decoration: none">WASL</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=NTN1" target="_blank" style="text-decoration: none">NTN1</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION" target="_blank" style="text-decoration: none">AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION</a></td><td>R</td><td>17</td><td>0.0337</td><td>0.9196</td><td>0.65</td><td>0.68</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=PYCR1" target="_blank" style="text-decoration: none">PYCR1</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=PHGDH" target="_blank" style="text-decoration: none">PHGDH</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON" target="_blank" style="text-decoration: none">ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON</a></td><td>R</td><td>14</td><td>0.0341</td><td>0.9647</td><td>0.05</td><td>0.89</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=TLR3" target="_blank" style="text-decoration: none">TLR3</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=TICAM1" target="_blank" style="text-decoration: none">TICAM1</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=RPS27A" target="_blank" style="text-decoration: none">RPS27A</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_TRNA_AMINOACYLATION" target="_blank" style="text-decoration: none">TRNA AMINOACYLATION</a></td><td>R</td><td>42</td><td>0.0342</td><td>0.9669</td><td>0.42</td><td>0.57</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=DARS" target="_blank" style="text-decoration: none">DARS</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=MARS" target="_blank" style="text-decoration: none">MARS</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=VARS2" target="_blank" style="text-decoration: none">VARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=YARS" target="_blank" style="text-decoration: none">YARS</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=YARS2" target="_blank" style="text-decoration: none">YARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=EPRS" target="_blank" style="text-decoration: none">EPRS</a> </td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CARS2" target="_blank" style="text-decoration: none">CARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=MARS2" target="_blank" style="text-decoration: none">MARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=TARS2" target="_blank" style="text-decoration: none">TARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=VARS2" target="_blank" style="text-decoration: none">VARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=SARS2" target="_blank" style="text-decoration: none">SARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=NARS2" target="_blank" style="text-decoration: none">NARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=FARS2" target="_blank" style="text-decoration: none">FARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=PARS2" target="_blank" style="text-decoration: none">PARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=IARS2" target="_blank" style="text-decoration: none">IARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=LARS2" target="_blank" style="text-decoration: none">LARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=WARS2" target="_blank" style="text-decoration: none">WARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=AARS2" target="_blank" style="text-decoration: none">AARS2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=QARS" target="_blank" style="text-decoration: none">QARS</a> </td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_TRNA_AMINOACYLATION" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY" target="_blank" style="text-decoration: none">RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT</a></td><td>R</td><td>12</td><td>0.0348</td><td>0.9819</td><td>0.43</td><td>1.00</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=MPG" target="_blank" style="text-decoration: none">MPG</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=LIG3" target="_blank" style="text-decoration: none">LIG3</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE" target="_blank" style="text-decoration: none">MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE</a></td><td>R</td><td>11</td><td>0.0382</td><td>0.9380</td><td>0.06</td><td>0.71</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=EXOSC6" target="_blank" style="text-decoration: none">EXOSC6</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN" target="_blank" style="text-decoration: none">REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN</a></td><td>R</td><td>25</td><td>0.0383</td><td>0.9864</td><td>0.14</td><td>0.78</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=RBX1" target="_blank" style="text-decoration: none">RBX1</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CREBBP" target="_blank" style="text-decoration: none">CREBBP</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=HIF3A" target="_blank" style="text-decoration: none">HIF3A</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS" target="_blank" style="text-decoration: none">PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS</a></td><td>R</td><td>16</td><td>0.0421</td><td>0.8915</td><td>0.00</td><td>0.57</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=LCK" target="_blank" style="text-decoration: none">LCK</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CD4" target="_blank" style="text-decoration: none">CD4</a> </td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CD3E" target="_blank" style="text-decoration: none">CD3E</a> </td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION" target="_blank" style="text-decoration: none">ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION</a></td><td>R</td><td>18</td><td>0.0482</td><td>0.9482</td><td>0.16</td><td>0.75</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=RIPK2" target="_blank" style="text-decoration: none">RIPK2</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=MAP3K7" target="_blank" style="text-decoration: none">MAP3K7</a> <a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=IRAK2" target="_blank" style="text-decoration: none">IRAK2</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_MTORC1_MEDIATED_SIGNALLING" target="_blank" style="text-decoration: none">MTORC1 MEDIATED SIGNALLING</a></td><td>R</td><td>11</td><td>0.0489</td><td>0.9736</td><td>0.12</td><td>0.81</td><td><a href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=EIF4E" target="_blank" style="text-decoration: none">EIF4E</a> </td><td></td><td><a href="http://biocomputing.tgen.org/PAH/ddns/PHBI_2/REACTOME_MTORC1_MEDIATED_SIGNALLING" target="_blank"><img src="../../../wp-content/uploads/2018/06/DDNImage.png" alt="Image" style="width:20px;height:20px;"></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" target="_blank" style="text-decoration: none">MITOCHONDRIAL FATTY ACID BETA OXIDATION</a></td><td>R</td><td>14</td><td>0.0548</td><td>0.9271</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS" target="_blank" style="text-decoration: none">SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS</a></td><td>R</td><td>12</td><td>0.0578</td><td>0.9175</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION" target="_blank" style="text-decoration: none">YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION</a></td><td>R</td><td>24</td><td>0.0605</td><td>0.9899</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_ADP_SIGNALLING_THROUGH_P2RY12" target="_blank" style="text-decoration: none">ADP SIGNALLING THROUGH P2RY12</a></td><td>R</td><td>21</td><td>0.0619</td><td>0.9807</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_ETHANOL_OXIDATION" target="_blank" style="text-decoration: none">ETHANOL OXIDATION</a></td><td>R</td><td>10</td><td>0.0661</td><td>0.9556</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_SYNTHESIS_OF_PE" target="_blank" style="text-decoration: none">SYNTHESIS OF PE</a></td><td>R</td><td>11</td><td>0.0682</td><td>0.9762</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS" target="_blank" style="text-decoration: none">THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS</a></td><td>R</td><td>28</td><td>0.0705</td><td>0.9723</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING" target="_blank" style="text-decoration: none">TRANSFERRIN ENDOCYTOSIS AND RECYCLING</a></td><td>R</td><td>25</td><td>0.0713</td><td>0.9779</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_DSCAM_INTERACTIONS" target="_blank" style="text-decoration: none">DSCAM INTERACTIONS</a></td><td>R</td><td>11</td><td>0.0772</td><td>0.8513</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA" target="_blank" style="text-decoration: none">G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA</a></td><td>R</td><td>25</td><td>0.0794</td><td>0.9773</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING" target="_blank" style="text-decoration: none">ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING</a></td><td>R</td><td>11</td><td>0.0815</td><td>0.9654</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_INFLAMMASOMES" target="_blank" style="text-decoration: none">INFLAMMASOMES</a></td><td>R</td><td>17</td><td>0.0838</td><td>0.9799</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY" target="_blank" style="text-decoration: none">TRAF3 DEPENDENT IRF ACTIVATION</a></td><td>R</td><td>14</td><td>0.0875</td><td>0.9435</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION" target="_blank" style="text-decoration: none">RNA POL I TRANSCRIPTION TERMINATION</a></td><td>R</td><td>22</td><td>0.0895</td><td>0.8987</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION" target="_blank" style="text-decoration: none">E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION</a></td><td>R</td><td>10</td><td>0.0910</td><td>0.9107</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_REGULATION_OF_KIT_SIGNALING" target="_blank" style="text-decoration: none">REGULATION OF KIT SIGNALING</a></td><td>R</td><td>17</td><td>0.0926</td><td>0.9504</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_GLYCOSPHINGOLIPID_METABOLISM" target="_blank" style="text-decoration: none">GLYCOSPHINGOLIPID METABOLISM</a></td><td>R</td><td>38</td><td>0.0937</td><td>0.9850</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_REGULATION_OF_SIGNALING_BY_CBL" target="_blank" style="text-decoration: none">REGULATION OF SIGNALING BY CBL</a></td><td>R</td><td>18</td><td>0.0955</td><td>0.9639</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA" target="_blank" style="text-decoration: none">OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA</a></td><td>R</td><td>18</td><td>0.0969</td><td>0.9557</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS" target="_blank" style="text-decoration: none">NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS</a></td><td>R</td><td>21</td><td>0.0978</td><td>0.9651</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT" target="_blank" style="text-decoration: none">ORGANIC CATION ANION ZWITTERION TRANSPORT</a></td><td>R</td><td>13</td><td>0.0987</td><td>0.9883</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><a href="http://www.broadinstitute.org/gsea/msigdb/cards/REACTOME_METABOLISM_OF_POLYAMINES" target="_blank" style="text-decoration: none">METABOLISM OF POLYAMINES</a></td><td>R</td><td>15</td><td>0.0999</td><td>0.9622</td><td></td><td></td><td></td><td></td><td></td></tr></table>